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Target
D(2) dopamine receptor
Ligand
BDBM50290223
Substrate
n/a
Meas. Tech.
ChEBML_58455
Ki
7.4±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50290223
Synonyms:
CHEMBL309979 | Cyclohexanecarboxylic acid (4-{2-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide
Type:
Small organic molecule
Emp. Form.:
C25H37Cl2N3O
Mol. Mass.:
466.487
SMILES:
Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)C3CCCCC3)CC2)c1Cl |wU:12.11,wD:15.18,(20.33,-3.82,;19.58,-5.18,;20.4,-6.5,;19.65,-7.84,;18.11,-7.88,;17.31,-6.55,;15.77,-6.59,;15.03,-7.93,;13.49,-7.96,;12.68,-6.65,;11.14,-6.69,;10.38,-8.03,;8.84,-8.03,;8.05,-9.36,;6.51,-9.38,;5.75,-8.04,;6.51,-6.71,;8.05,-6.69,;4.21,-8.05,;3.44,-9.38,;1.89,-9.38,;4.21,-10.72,;5.74,-10.71,;6.5,-12.04,;5.73,-13.36,;4.19,-13.36,;3.44,-12.04,;13.43,-5.31,;14.97,-5.27,;18.05,-5.21,;17.24,-3.89,)|
Structure:
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