Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50290210
Substrate
n/a
Meas. Tech.
ChEBML_58772
Ki
2±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50290210
Synonyms:
CHEMBL78368 | Thiophene-2-carboxylic acid (4-{2-[4-(3-chloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide
Type:
Small organic molecule
Emp. Form.:
C23H30ClN3OS
Mol. Mass.:
432.022
SMILES:
Clc1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)c2cccs2)CC1 |wU:13.13,wD:16.20,(18.02,-2.32,;17.27,-3.67,;18.09,-5,;17.34,-6.35,;15.8,-6.38,;15.01,-5.06,;15.75,-3.72,;13.47,-5.09,;12.74,-6.42,;11.2,-6.46,;10.39,-5.16,;8.85,-5.19,;8.1,-6.52,;6.56,-6.53,;5.77,-7.86,;4.23,-7.87,;3.48,-6.54,;4.23,-5.21,;5.77,-5.2,;1.94,-6.54,;1.17,-7.87,;-.37,-7.89,;1.94,-9.2,;3.46,-9.29,;3.32,-11.95,;1.78,-11.86,;1.08,-10.5,;11.14,-3.81,;12.68,-3.78,)|
Structure:
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