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Target
Proteinase-activated receptor 1
Ligand
BDBM50070657
Substrate
n/a
Meas. Tech.
ChEBML_209250
IC50
5700±n/a nM
Citation
 Hoekstra, WJ; Hulshizer, BL; McComsey, DF; Andrade-Gordon, P; Kauffman, JA; Addo, MF; Oksenberg, D; Scarborough, RM; Maryanoff, BE Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif. Bioorg Med Chem Lett 8:1649-54 (1999) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50070657
Synonyms:
2-[(S)-2-(4-Fluoro-phenyl)-1-(2-methylamino-acetylamino)-ethyl]-thiazole-4-carboxylic acid {(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butylcarbamoyl]-2-cyclohexyl-ethyl}-amide | CHEMBL288976
Type:
Small organic molecule
Emp. Form.:
C39H53FN10O5S
Mol. Mass.:
792.966
SMILES:
CNCC(=O)N[C@@H](Cc1ccc(F)cc1)c1nc(cs1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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