Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50071213
Substrate
n/a
Meas. Tech.
ChEBML_201032
IC50
100±n/a nM
Citation
 Arlt, M; Böttcher, H; Riethmüller, A; Schneider, G; Bartoszyk, GD; Greiner, H; Seyfried, CA SAR of novel biarylmethylamine dopamine D4 receptor ligands. Bioorg Med Chem Lett 8:2033-8 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50071213
Synonyms:
2-{4-[5-(4-Fluoro-phenyl)-pyridin-3-ylmethyl]-piperazin-1-yl}-pyrimidine | CHEMBL302183
Type:
Small organic molecule
Emp. Form.:
C20H20FN5
Mol. Mass.:
349.4047
SMILES:
Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2ncccn2)c1
Structure:
Search PDB for entries with ligand similarity: