Reaction Details Report a problem with these data
Target
Neuromedin-B receptor
Ligand
BDBM50071737
Substrate
n/a
Meas. Tech.
ChEBML_39622
Ki
0.970000±n/a nM
Citation
 Ashwood, V; Brownhill, V; Higginbottom, M; Horwell, DC; Hughes, J; Lewthwaite, RA; McKnight, AT; Pinnock, RD; Pritchard, MC; Suman-Chauhan, N; Webb, C; Williams, SC PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett 8:2589-94 (1999) [PubMed]  Article 
Target
Name:
Neuromedin-B receptor
Synonyms:
Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43447.11
Organism:
Homo sapiens (Human)
Description:
Bombesin 1 NMBR 0::P28336
Residue:
390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
  
Inhibitor
Name:
BDBM50071737
Synonyms:
(S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(3-nitro-phenyl)-ureido]-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide | CHEMBL313346
Type:
Small organic molecule
Emp. Form.:
C31H34N6O4
Mol. Mass.:
554.6395
SMILES:
C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1cccc(c1)[N+]([O-])=O)C(=O)NCC1(CCCCC1)c1ccccn1
Structure:
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