Reaction Details Report a problem with these data
Target
Macrophage metalloelastase
Ligand
BDBM50068852
Substrate
n/a
Meas. Tech.
ChEBML_103854
IC50
67±n/a nM
Citation
 Jeng, AY; Chou, M; Parker, DT Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorg Med Chem Lett 8:897-902 (1999) [PubMed]  Article 
Target
Name:
Macrophage metalloelastase
Synonyms:
MMP12_MOUSE | Matrix metalloproteinase 12 | Mme | Mmel | Mmp12
Type:
PROTEIN
Mol. Mass.:
54988.61
Organism:
Mus musculus
Description:
ChEMBL_796155
Residue:
473
Sequence:
MSCTLLKGVCTMKFLMMIVFLQVSACGAAPMNDSEFAEWYLSRFYDYGKDRIPMTKTKTNRNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKREDVDYIFQKAFQVWSDVTPLRFRKLHKDEADIMILFAFGAHGDFNYFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDIRNIQSLYGAPVKPPSLTKPSSPPSTFCHQSLSFDAVTTVGEKIFFFKDWFFWWKLPGSPATNITSISSIWPSIPSGIQAAYEIESRNQLFLFKDEKYWLINNLVPEPHYPRSIYSLGFSASVKKVDAAVFDPLRQKVYFFVDKHYWRYDVRQELMDPAYPKLISTHFPGIKPKIDAVLYFKRHYYIFQGAYQLEYDPLFRRVTKTLKSTSWFGC
  
Inhibitor
Name:
BDBM50068852
Synonyms:
CHEMBL265476 | {(R)-5-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-5-hydroxycarbamoyl-pentyl}-carbamic acid phenyl ester
Type:
Small organic molecule
Emp. Form.:
C27H31N3O7S
Mol. Mass.:
541.616
SMILES:
COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CCCCNC(=O)Oc1ccccc1)C(=O)NO
Structure:
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