Reaction Details Report a problem with these data
Target
Macrophage metalloelastase
Ligand
BDBM50068854
Substrate
n/a
Meas. Tech.
ChEBML_103854
IC50
>100±n/a nM
Citation
 Jeng, AY; Chou, M; Parker, DT Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorg Med Chem Lett 8:897-902 (1999) [PubMed]  Article 
Target
Name:
Macrophage metalloelastase
Synonyms:
MMP12_MOUSE | Matrix metalloproteinase 12 | Mme | Mmel | Mmp12
Type:
PROTEIN
Mol. Mass.:
54988.61
Organism:
Mus musculus
Description:
ChEMBL_796155
Residue:
473
Sequence:
MSCTLLKGVCTMKFLMMIVFLQVSACGAAPMNDSEFAEWYLSRFYDYGKDRIPMTKTKTNRNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKREDVDYIFQKAFQVWSDVTPLRFRKLHKDEADIMILFAFGAHGDFNYFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDIRNIQSLYGAPVKPPSLTKPSSPPSTFCHQSLSFDAVTTVGEKIFFFKDWFFWWKLPGSPATNITSISSIWPSIPSGIQAAYEIESRNQLFLFKDEKYWLINNLVPEPHYPRSIYSLGFSASVKKVDAAVFDPLRQKVYFFVDKHYWRYDVRQELMDPAYPKLISTHFPGIKPKIDAVLYFKRHYYIFQGAYQLEYDPLFRRVTKTLKSTSWFGC
  
Inhibitor
Name:
BDBM50068854
Synonyms:
(R)-2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-2-piperidin-4-yl-acetamide | CHEMBL354635
Type:
Small organic molecule
Emp. Form.:
C21H27N3O5S
Mol. Mass.:
433.521
SMILES:
COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](C1CCNCC1)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: