Reaction Details Report a problem with these data
Target
DNA topoisomerase 1
Ligand
BDBM50081427
Substrate
n/a
Meas. Tech.
ChEBML_208411
IC50
172000±n/a nM
Citation
Sato, S; Suga, Y; Yoshimura, T; Nakagawa, R; Tsuji, T; Umemura, K; Andoh, T Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II. Bioorg Med Chem Lett 9:2653-6 (1999) [PubMed] Article
More Info.:
Target
Name:
DNA topoisomerase 1
Synonyms:
DNA topoisomerase I | TOP1_MOUSE | Top-1 | Top1
Type:
PROTEIN
Mol. Mass.:
90922.04
Organism:
Mus musculus
Description:
ChEMBL_208411
Residue:
767
Sequence:
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF