Target
Histidine--tRNA ligase, cytoplasmic
Ligand
BDBM50091516
Substrate
n/a
Meas. Tech.
ChEBML_87383
IC50
130±n/a nM
Citation
 Forrest, AKJarvest, RLMensah, LMO'Hanlon, PJPope, AJSheppard, RJ Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases. Bioorg Med Chem Lett 10:1871-4 (2000) [PubMed]  Article 
Target
Name:
Histidine--tRNA ligase, cytoplasmic
Synonyms:
HARS | HARS1 | HARS1_HUMAN | HRS | HisRS | Histidine--tRNA ligase | Histidyl-tRNA synthetase | Histidyl-tRNA synthetase, cytoplasmic
Type:
PROTEIN
Mol. Mass.:
57406.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_87383
Residue:
509
Sequence:
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC
  
Inhibitor
Name:
BDBM50091516
Synonyms:
5'-O-[(L-HISTIDYLAMINO)SULFONYL]ADENOSINE | CHEMBL412891 | HisSA | [(S)-2-Amino-3-(1H-imidazol-4-yl)-propionyl]-sulfamic acid (2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C16H21N9O7S
Mol. Mass.:
483.459
SMILES:
N[C@@H](Cc1cnc[nH]1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: