Reaction Details Report a problem with these data
Target
Histidine--tRNA ligase, cytoplasmic
Ligand
BDBM50091516
Substrate
n/a
Meas. Tech.
ChEBML_87383
IC50
130±n/a nM
Citation
Forrest, AK; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ; Sheppard, RJ Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases. Bioorg Med Chem Lett 10:1871-4 (2000) [PubMed] Article
More Info.:
Target
Name:
Histidine--tRNA ligase, cytoplasmic
Synonyms:
HARS | HARS1 | HARS1_HUMAN | HRS | HisRS | Histidine--tRNA ligase | Histidyl-tRNA synthetase | Histidyl-tRNA synthetase, cytoplasmic
Type:
PROTEIN
Mol. Mass.:
57406.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_87383
Residue:
509
Sequence:
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC
Inhibitor
Name:
BDBM50091516
Synonyms:
5'-O-[(L-HISTIDYLAMINO)SULFONYL]ADENOSINE | CHEMBL412891 | HisSA | [(S)-2-Amino-3-(1H-imidazol-4-yl)-propionyl]-sulfamic acid (2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C16H21N9O7S
Mol. Mass.:
483.459
SMILES:
N[C@@H](Cc1cnc[nH]1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12