Reaction Details Report a problem with these data
Target
Arginine--tRNA ligase, cytoplasmic
Ligand
BDBM50091518
Substrate
n/a
Meas. Tech.
ChEBML_36050
IC50
7.5±n/a nM
Citation
Forrest, AK; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ; Sheppard, RJ Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases. Bioorg Med Chem Lett 10:1871-4 (2000) [PubMed] Article
More Info.:
Target
Name:
Arginine--tRNA ligase, cytoplasmic
Synonyms:
ArgRS | Arginine--tRNA ligase | Arginyl-tRNA synthetase | Arginyl-tRNA synthetase, cytoplasmic | RARS | RARS1 | SYRC_HUMAN
Type:
PROTEIN
Mol. Mass.:
75379.14
Organism:
Homo sapiens (Human)
Description:
ChEMBL_36050
Residue:
660
Sequence:
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM
Inhibitor
Name:
BDBM50091518
Synonyms:
CHEMBL434782 | Phosphoric acid (S)-2-amino-5-guanidino-pentyl ester (2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C16H28N9O7P
Mol. Mass.:
489.4234
SMILES:
N[C@@H](CCCNC(N)=[NH2+])COP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12