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Target
Beta-lactamase
Ligand
BDBM50092275
Substrate
n/a
Meas. Tech.
ChEBML_41358
IC50
>700000±n/a nM
Citation
 Grant, EB; Guiadeen, D; Baum, EZ; Foleno, BD; Jin, H; Montenegro, DA; Nelson, EA; Bush, K; Hlasta, DJ The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors. Bioorg Med Chem Lett 10:2179-82 (2001) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase TEM
Type:
PROTEIN
Mol. Mass.:
31512.33
Organism:
Enterobacter cloacae
Description:
ChEMBL_41358
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50092275
Synonyms:
5-[1-(1-Phenyl-1H-[1,2,3]triazol-4-yl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one | CHEMBL302252
Type:
Small organic molecule
Emp. Form.:
C12H8N4OS2
Mol. Mass.:
288.348
SMILES:
SC1=NC(=O)C(S1)=Cc1cn(nn1)-c1ccccc1 |w:7.8,t:1|
Structure:
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