Reaction Details Report a problem with these data
Target
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Ligand
BDBM50085483
Substrate
n/a
Meas. Tech.
ChEBML_223410
Ki
10±n/a nM
Citation
 de L Ufret, M; Imperiali, B Probing the extended binding determinants of oligosaccharyl transferase with synthetic inhibitors of asparagine-linked glycosylation. Bioorg Med Chem Lett 10:281-4 (2000) [PubMed]  Article 
Target
Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Synonyms:
DDOST | DDOST 48 kDa subunit | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit | KIAA0115 | OST48 | OST48_HUMAN | Oligosaccharyl transferase 48 kDa subunit
Type:
PROTEIN
Mol. Mass.:
50800.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_223410
Residue:
456
Sequence:
MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
  
Inhibitor
Name:
BDBM50085483
Synonyms:
(2-{(3R,6S)-3-[(1S,2R)-2-Hydroxy-1-((S)-1-{(1S,2R)-2-hydroxy-1-[2-(4-nitro-phenyl)-ethylcarbamoyl]-propylcarbamoyl}-2-methyl-propylcarbamoyl)-propylcarbamoyl]-5,8-dioxo-1-thia-4,7-diaza-cyclotridec-6-yl}-ethyl)-naphthalen-2-yl-ammonium | CID44328456 | synthetic asparagine-linked glycosylation inhibitors 13
Type:
Small organic molecule
Emp. Form.:
C44H61N8O10S
Mol. Mass.:
894.067
SMILES:
CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH2+]c2ccc3ccccc3c2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: