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TargetSodium-dependent noradrenaline transporter
LigandBDBM50085506
Substrate/Competitorn/a
Meas. Tech.ChEMBL_142803
IC50 2.2±n/a nM
Citation Tamiz, APSmith, MPKozikowski, AP Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine. Bioorg Med Chem Lett10:297-300 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Sodium-dependent noradrenaline transporter
Synonyms:NET | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SLC6A2 | Serotonin Transporter (SERT) | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (human)
Description:Competition binding assay was determined using hNET stably expressed in HEK293 cells.
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50085506
NameBDBM50085506
Synonyms:(1R,3S)-5-Methylene-3-p-tolyl-7-aza-tricyclo[5.3.0.0*4,8*]decane | CHEMBL101905
TypeSmall organic molecule
Emp. Form.C17H21N
Mol. Mass.239.3553
SMILESCc1ccc(cc1)[C@H]1C[C@H]2CCC3C1C(=C)CN23 |TLB:10:9:12:14.16,THB:16:17:13.7.8:11.10,4:7:12:14.16|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a