Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM3556
Substrate
n/a
Meas. Tech.
ChEBML_157940
IC50
>10000±n/a nM
Citation
 Wright, SW; Hageman, DL; McClure, LD; Carlo, AA; Treadway, JL; Mathiowetz, AM; Withka, JM; Bauer, PH Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines. Bioorg Med Chem Lett 11:17-21 (2001) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_PIG | FBP | FBP1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36781.07
Organism:
Sus scrofa (Pig)
Description:
Liver FBPase (P00636)
Residue:
338
Sequence:
MTDQAAFDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK
  
Inhibitor
Name:
BDBM3556
Synonyms:
4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline | CHEMBL1204199 | CHEMBL35820 | N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine | PD153035 Analog | PD153035 Analog 56
Type:
Small organic molecule
Emp. Form.:
C18H18BrN3O2
Mol. Mass.:
388.258
SMILES:
CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC
Structure:
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