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TargetFructose-1,6-bisphosphatase 1 (FBPase)
LigandBDBM3032
Substrate/Competitorn/a
Meas. Tech.ChEBML_86713
IC50 1000±n/a nM
Citation Wright, SWHageman, DLMcClure, LDCarlo, AATreadway, JLMathiowetz, AMWithka, JMBauer, PH Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines. Bioorg Med Chem Lett11:17-21 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphatase 1 (FBPase)
Name:Fructose-1,6-bisphosphatase
Synonyms:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1
Type:Protein
Mol. Mass.:36843.58
Organism:Homo sapiens (Human)
Description:Liver FBPase (P09467)
Residue:338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM3032
NameBDBM3032
Synonyms:CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine | PD153035 | US9422297, PD153035
TypeSmall organic molecule
Emp. Form.C16H14BrN3O2
Mol. Mass.360.205
SMILESCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a