Reaction Details
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Sodium- and chloride-dependent glycine transporter 2
Ligand
BDBM50099873
Substrate
n/a
Meas. Tech.
ChEBML_72767
IC50
1160±n/a nM
Citation
Isaac, M; Slassi, A; Silva, KD; Arora, J; MacLean, N; Hung, B; McCallum, K 5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors. Bioorg Med Chem Lett 11:1371-3 (2001) [PubMed] Article More Info.:
Target
Name:
Sodium- and chloride-dependent glycine transporter 2
Synonyms:
Glycine transporter 2 | Glyt2 | SC6A5_RAT | Slc6a5
Type:
PROTEIN
Mol. Mass.:
87845.43
Organism:
Rattus norvegicus
Description:
ChEMBL_980598
Residue:
799
Sequence:
MDCSAPKEMNKPPTNILEATVPGHRDSPRAPRTSPEQDLPAAAPAAAVQPPRVPRSASTGAQTFQSADARACEAQRPGVGFCKLSSPQAQATSAALRDLSEGHSAQANPPSGAAGAGNALHCKIPALRGPEEDENVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
Inhibitor
Name:
BDBM50099873
Synonyms:
CHEMBL29964 | Sodium; (E)-2-amino-5-(4-isopropyl-phenyl)-5-(4-methoxy-phenyl)-pent-4-enoate
Type:
Small organic molecule
Emp. Form.:
C21H24NO3
Mol. Mass.:
338.4207
SMILES:
COc1ccc(cc1)C(=C\CC(N)C([O-])=O)\c1ccc(cc1)C(C)C
Structure:
