Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50081953
Substrate
n/a
Meas. Tech.
ChEBML_152560
Ki
480±n/a nM
Citation
 Grunewald, GL; McLeish, MJ; Criscione, KR Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme. Bioorg Med Chem Lett 11:1579-82 (2001) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50081953
Synonyms:
((S)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol | CHEMBL342625
Type:
Small organic molecule
Emp. Form.:
C10H12BrNO
Mol. Mass.:
242.112
SMILES:
OC[C@@H]1Cc2ccc(Br)cc2CN1
Structure:
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