Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50101388
Substrate
n/a
Meas. Tech.
ChEBML_45271
Ki
63±n/a nM
Citation
 Mincione, F; Starnotti, M; Menabuoni, L; Scozzafava, A; Casini, A; Supuran, CT Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. Bioorg Med Chem Lett 11:1787-91 (2001) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM50101388
Synonyms:
4-Chloro-3-sulfamoyl-N-[2-(4-sulfamoyl-phenyl)-ethyl]-benzamide | CHEMBL53607
Type:
Small organic molecule
Emp. Form.:
C15H16ClN3O5S2
Mol. Mass.:
417.888
SMILES:
NS(=O)(=O)c1ccc(CCNC(=O)c2ccc(Cl)c(c2)S(N)(=O)=O)cc1
Structure:
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