Reaction Details
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4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
Ligand
BDBM50101904
Substrate
n/a
Meas. Tech.
ChEMBL_69265 (CHEMBL677083)
IC50
45000±n/a nM
Citation
Schuster, M; Blechert, S Inhibition of fucosyltransferase V by a GDP-Azasugar. Bioorg Med Chem Lett 11:1809-11 (2001) [PubMed] Article More Info.:
Target
Name:
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
Synonyms:
FUT5 | FUT5_HUMAN | Fucosyltransferase 5
Type:
PROTEIN
Mol. Mass.:
43016.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_69264
Residue:
374
Sequence:
MDPLGPAKPQWLWRRCLAGLLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPNGSRCQDSMATPAHPTLLILLWTWPFNTPVALPRCSEMVPGAADCNITADSSVYPQADAVIVHHWDIMYNPSANLPPPTRPQGQRWIWFSMESPSNCRHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQQESRYQTVRSIAAWFT
Inhibitor
Name:
BDBM50101904
Synonyms:
CHEMBL52741 | GDP-Azasugar analogue
Type:
Small organic molecule
Emp. Form.:
C16H26N6O13P2
Mol. Mass.:
572.3576
SMILES:
C[C@@H]1[NH2+][C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc([NH3+])[nH]c3=O)[C@@H](O)[C@@H]1O
Structure:
