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Target
Protein phosphatase 1B
Ligand
BDBM50106039
Substrate
n/a
Meas. Tech.
ChEBML_161764
IC50
>1000000±n/a nM
Citation
 McCluskey, A; Walkom, C; Bowyer, MC; Ackland, SP; Gardiner, E; Sakoff, JA Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A. Bioorg Med Chem Lett 11:2941-6 (2001) [PubMed]  Article 
Target
Name:
Protein phosphatase 1B
Synonyms:
PP2C-beta | PP2CB | PPM1B | PPM1B_HUMAN | Protein phosphatase 1B | Protein phosphatase 2C beta | Protein phosphatase 2C isoform beta
Type:
PROTEIN
Mol. Mass.:
52620.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161756
Residue:
479
Sequence:
MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI
  
Inhibitor
Name:
BDBM50106039
Synonyms:
(S)-2-((1S,2R,6S,7R)-3,5-Dioxo-10-oxa-4-aza-tricyclo[5.2.1.0*2,6*]dec-4-yl)-4-methyl-pentanoic acid | CHEMBL101983
Type:
Small organic molecule
Emp. Form.:
C14H19NO5
Mol. Mass.:
281.3044
SMILES:
CC(C)C[C@H](N1C(=O)[C@H]2[C@@H]3CC[C@@H](O3)[C@H]2C1=O)C(O)=O
Structure:
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