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Target
Steryl-sulfatase
Ligand
BDBM50051829
Substrate
n/a
Meas. Tech.
ChEBML_68018
IC50
12000±n/a nM
Citation
 Ahmed, S; James, K; Owen, CP; Patel, CK; Patel, M Novel inhibitors of the enzyme estrone sulfatase (ES). Bioorg Med Chem Lett 11:841-4 (2001) [PubMed]  Article 
Target
Name:
Steryl-sulfatase
Synonyms:
ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase
Type:
Enzyme
Mol. Mass.:
65503.66
Organism:
Homo sapiens (Human)
Description:
P08842
Residue:
583
Sequence:
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
  
Inhibitor
Name:
BDBM50051829
Synonyms:
4-methyl-2-oxo-2H-chromen-7-yl sulfamate | CHEMBL11185 | Sulfamic acid 4-methyl-2-oxo-2H-chromen-7-yl ester
Type:
Small organic molecule
Emp. Form.:
C10H9NO5S
Mol. Mass.:
255.247
SMILES:
Cc1cc(=O)oc2cc(OS(N)(=O)=O)ccc12
Structure:
Search PDB for entries with ligand similarity: