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Target
Collagenase 3
Ligand
BDBM50098914
Substrate
n/a
Meas. Tech.
ChEBML_106619
IC50
2.1±n/a nM
Citation
 Pikul, S; Dunham, KM; Almstead, NG; De, B; Natchus, MG; Taiwo, YO; Williams, LE; Hynd, BA; Hsieh, LC; Janusz, MJ; Gu, F; Mieling, GE Heterocycle-based MMP inhibitors with P2' substituents. Bioorg Med Chem Lett 11:1009-13 (2001) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
Collagenase 3 | MMP-13 | MMP13_RAT | Matrix metalloproteinase 13 | Matrix metalloproteinase-13 | Mmp13 | UMRCASE
Type:
PROTEIN
Mol. Mass.:
53359.23
Organism:
Rattus norvegicus
Description:
ChEMBL_424298
Residue:
466
Sequence:
ATFFLLSWTHCWSLPLPYGDDDDDDLSEEDLEFAEHYLKSYYHPVTLAGILKKSTVTSTVDRLREMQSFFGLDVTGKLDDPTLDIMRKPRCGVPDVGVYNVFPRTLKWSQTNLTYRIVNYTPDISHSEVEKAFRKAFKVWSDVTPLNFTRIHDGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNLGGDAHFDDDETWTSSSKGYNLFIVAAHELGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPEKCDPALSLDAITSLRGETMIFKDRFFWRLHPQQVEPELFLTKSFWPELPNHVDAAYEHPSRDLMFIFRGRKFWALNGYDIMEGYPRKISDLGFPKEVKRLSAAVHFEDTGKTLFFSGNHVWSYDDANQTMDKDYPRLIEEEFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPTNSLLWC
  
Inhibitor
Name:
BDBM50098914
Synonyms:
(R)-5-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-[1,4]diazepane-1-carboxylic acid benzyl ester | CHEMBL267939
Type:
Small organic molecule
Emp. Form.:
C21H25N3O7S
Mol. Mass.:
463.504
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCN(CC[C@@H]1C(=O)NO)C(=O)OCc1ccccc1
Structure:
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