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Target
Substance-K receptor
Ligand
BDBM50116088
Substrate
n/a
Meas. Tech.
ChEBML_209384
Ki
0.600000±n/a nM
Citation
 Ting, PC; Lee, JF; Shih, NY; Piwinski, JJ; Anthes, JC; Chapman, RW; Rizzo, CA; Hey, JA; Ng, K; Nomeir, AA Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist. Bioorg Med Chem Lett 12:2125-8 (2002) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK2R_CAVPO | Neurokinin 2 receptor | Neurokinin NK2 | Substance-K receptor | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45106.00
Organism:
GUINEA PIG
Description:
Neurokinin NK2 TACR2 GUINEA PIG::Q64077
Residue:
402
Sequence:
MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMAGDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS
  
Inhibitor
Name:
BDBM50116088
Synonyms:
3,5-Dichloro-N-(3-(3,4-dichloro-phenyl)-5-{3-[2-(2-hydroxy-azetidin-1-yl)-2-oxo-ethyl]-2-oxo-[1,4']bipiperidinyl-1'-yl}-2-methoxyimino-pentyl)-N-ethyl-benzamide | CHEMBL68234
Type:
Small organic molecule
Emp. Form.:
C35H43Cl4N5O5
Mol. Mass.:
755.558
SMILES:
CO\N=C(/CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(CC1)N1CCCC(CC(=O)N2CC(O)C2)C1=O)c1ccc(Cl)c(Cl)c1
Structure:
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