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Target
cGMP-specific 3',5'-cyclic phosphodiesterase
Ligand
BDBM50116710
Substrate
n/a
Meas. Tech.
ChEBML_155368
IC50
10600±n/a nM
Citation
 Shin, HJ; Kim, HJ; Kwak, JH; Chun, HO; Kim, JH; Park, H; Kim, DH; Lee, YS A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett 12:2313-6 (2002) [PubMed]  Article 
Target
Name:
cGMP-specific 3',5'-cyclic phosphodiesterase
Synonyms:
PDE5A_RAT | Pde5 | Pde5a | Phosphodiesterase 5A
Type:
PROTEIN
Mol. Mass.:
94547.60
Organism:
Rattus norvegicus
Description:
ChEMBL_155367
Residue:
833
Sequence:
MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREHDANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD
  
Inhibitor
Name:
BDBM50116710
Synonyms:
(2R,3S)-2-(2,4-Dihydroxy-phenyl)-3,7-dihydroxy-8-(5-hydroxy-2-isopropenyl-5-methyl-hexyl)-5-methoxy-chroman-4-one | CHEMBL440494
Type:
Small organic molecule
Emp. Form.:
C26H32O8
Mol. Mass.:
472.5275
SMILES:
COc1cc(O)c(CC(CCC(C)(C)O)C(C)=C)c2O[C@@H]([C@H](O)C(=O)c12)c1ccc(O)cc1O
Structure:
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