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Target
Serum paraoxonase/arylesterase 1
Ligand
BDBM50127646
Substrate
n/a
Meas. Tech.
ChEBML_152860
IC50
1280000±n/a nM
Citation
 Bargota, RS; Akhtar, M; Biggadike, K; Gani, D; Allemann, RK Structure-activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors. Bioorg Med Chem Lett 13:1623-6 (2003) [PubMed]  Article 
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1)
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Homo sapiens (Human)
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
  
Inhibitor
Name:
BDBM50127646
Synonyms:
CHEMBL42577 | Phosphoric acid 4-amino-phenyl ester diethyl ester
Type:
Small organic molecule
Emp. Form.:
C10H16NO4P
Mol. Mass.:
245.2121
SMILES:
CCOP(=O)(OCC)Oc1ccc(N)cc1
Structure:
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