Reaction Details
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Ligand
BDBM50366835
Substrate
n/a
Meas. Tech.
ChEMBL_216151 (CHEMBL817034)
Ki
5100000±n/a nM
Citation
Whalen, LJ; McEvoy, KA; Halcomb, RL Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases. Bioorg Med Chem Lett 13:301-4 (2002) [PubMed] Article More Info.:
Target
Name:
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Synonyms:
SIAT6_RAT | Siat6 | St3gal3
Type:
PROTEIN
Mol. Mass.:
42091.50
Organism:
Rattus norvegicus
Description:
ChEMBL_649270
Residue:
374
Sequence:
MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEDSNSLILSLDSAGQTLGTEYDRLGFLLKLDSKLPAELATKYANFSEGACKPGYASAMMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALDGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSGI
Inhibitor
Name:
BDBM50366835
Synonyms:
CHEMBL609514
Type:
Small organic molecule
Emp. Form.:
C13H19N4O11P
Mol. Mass.:
438.2839
SMILES:
Nc1ccn(C2O[C@H](COP(O)(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](O)[C@H]2O)c(=O)n1 |r|
Structure:
