Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50133799
Substrate
n/a
Meas. Tech.
ChEBML_41922
IC50
8500±n/a nM
Citation
 Gong, L; Hogg, JH; Collier, J; Wilhelm, RS; Soderberg, C Design and synthesis of novel CCR3 antagonists. Bioorg Med Chem Lett 13:3597-600 (2003) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50133799
Synonyms:
4-Methyl-N-{2-methyl-1-[1-(4-nitro-benzyl)-piperidin-4-ylmethyl]-propyl}-benzamide | CHEMBL333040
Type:
Small organic molecule
Emp. Form.:
C25H33N3O3
Mol. Mass.:
423.5478
SMILES:
CC(C)C(CC1CCN(Cc2ccc(cc2)[N+]([O-])=O)CC1)NC(=O)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: