Reaction Details Report a problem with these data
Target
Lecithin retinol acyltransferase
Ligand
BDBM19
Substrate
n/a
Meas. Tech.
ChEMBL_96915 (CHEMBL707894)
IC50
14900±n/a nM
Citation
 Ryu, DH; Tan, CH; Rando, RR Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics. Bioorg Med Chem Lett 13:901-3 (2003) [PubMed]  Article 
Target
Name:
Lecithin retinol acyltransferase
Synonyms:
LRAT | LRAT_HUMAN | Lecithin retinol acyltransferase | Phosphatidylcholine--retinol O-acyltransferase | Phosphatidylcholine-retinol O-acyltransferase
Type:
PROTEIN
Mol. Mass.:
25705.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_96915
Residue:
230
Sequence:
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG
  
Inhibitor
Name:
BDBM19
Synonyms:
(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol | KDR Kinase Inhibitor, 3 | Neomycin | Neomycin B
Type:
Small organic molecule
Emp. Form.:
C23H46N6O13
Mol. Mass.:
614.6437
SMILES:
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O |r|
Structure:
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