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Target
Methionine aminopeptidase 2
Ligand
BDBM50137408
Substrate
n/a
Meas. Tech.
ChEBML_105146
IC50
1.2±n/a nM
Citation
 Pyun, HJ; Fardis, M; Tario, J; Yang, CY; Ruckman, J; Henninger, D; Jin, H; Kim, CU Investigation of novel fumagillin analogues as angiogenesis inhibitors. Bioorg Med Chem Lett 14:91-4 (2003) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM50137408
Synonyms:
CHEMBL172883 | Carbamic acid (3R,4S,5S,6R)-4-{1-[(E)-benzyloxyimino]-ethyl}-5-methoxy-1-oxa-spiro[2.5]oct-6-yl ester
Type:
Small organic molecule
Emp. Form.:
C18H24N2O5
Mol. Mass.:
348.3936
SMILES:
CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1\C(C)=N\OCc1ccccc1)OC(N)=O
Structure:
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