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Target
Collagenase 3
Ligand
BDBM50148200
Substrate
n/a
Meas. Tech.
ChEMBL_106600 (CHEMBL717437)
IC50
17±n/a nM
Citation
 Reiter, LA; Robinson, RP; McClure, KF; Jones, CS; Reese, MR; Mitchell, PG; Otterness, IG; Bliven, ML; Liras, J; Cortina, SR; Donahue, KM; Eskra, JD; Griffiths, RJ; Lame, ME; Lopez-Anaya, A; Martinelli, GJ; McGahee, SM; Yocum, SA; Lopresti-Morrow, LL; Tobiassen, LM; Vaughn-Bowser, ML Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett 14:3389-95 (2004) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50148200
Synonyms:
CHEMBL114378 | N-Hydroxy-2-(4-methoxy-benzenesulfonylamino)-2-methyl-propionamide
Type:
Small organic molecule
Emp. Form.:
C11H16N2O5S
Mol. Mass.:
288.32
SMILES:
COc1ccc(cc1)S(=O)(=O)NC(C)(C)C(=O)NO
Structure:
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