Target
Collagenase 3
Ligand
BDBM50148206
Substrate
n/a
Meas. Tech.
ChEMBL_106600 (CHEMBL717437)
IC50
5±n/a nM
Citation
 Reiter, LARobinson, RPMcClure, KFJones, CSReese, MRMitchell, PGOtterness, IGBliven, MLLiras, JCortina, SRDonahue, KMEskra, JDGriffiths, RJLame, MELopez-Anaya, AMartinelli, GJMcGahee, SMYocum, SALopresti-Morrow, LLTobiassen, LMVaughn-Bowser, ML Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett 14:3389-95 (2004) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50148206
Synonyms:
4-[4-(Naphthalen-2-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | CHEMBL325903
Type:
Small organic molecule
Emp. Form.:
C22H22N2O6S
Mol. Mass.:
442.485
SMILES:
ONC(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Oc2ccc3ccccc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: