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Target
Thromboxane-A synthase
Ligand
BDBM50028758
Substrate
n/a
Meas. Tech.
ChEBML_210444
IC50
25±n/a nM
Citation
 Tanouchi, T; Kawamura, M; Ohyama, I; Kajiwara, I; Iguchi, Y; Okada, T; Miyamoto, T; Taniguchi, K; Hayashi, M; Iizuka, K; Nakazawa, M Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives. J Med Chem 24:1149-55 (1982) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50028758
Synonyms:
2-Methyl-3-[4-(1-pyridin-3-yl-ethyl)-phenyl]-acrylic acid; hydrochloride | CHEMBL553319
Type:
Small organic molecule
Emp. Form.:
C17H17NO2
Mol. Mass.:
267.3224
SMILES:
CC(c1ccc(\C=C(/C)C(O)=O)cc1)c1cccnc1
Structure:
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