Reaction Details Report a problem with these data
Target
Pyruvate kinase PKM
Ligand
BDBM50367054
Substrate
n/a
Meas. Tech.
ChEBML_160380
Ki
3700000±n/a nM
Citation
 Hai, TT; Abo, M; Hampton, A Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives. J Med Chem 25:1184-8 (1983) [PubMed]  Article 
Target
Name:
Pyruvate kinase PKM
Synonyms:
KPYM_RAT | Pkm | Pkm2 | Pykm | Pyruvate kinase isozymes M1/M2
Type:
PROTEIN
Mol. Mass.:
57820.70
Organism:
Rattus norvegicus
Description:
ChEMBL_160255
Residue:
531
Sequence:
MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
  
Inhibitor
Name:
BDBM50367054
Synonyms:
CHEMBL606476
Type:
Small organic molecule
Emp. Form.:
C12H19N5O10P2S
Mol. Mass.:
487.319
SMILES:
CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: