Reaction Details Report a problem with these data
Target
GTP:AMP phosphotransferase AK3, mitochondrial
Ligand
BDBM50367075
Substrate
n/a
Meas. Tech.
ChEBML_32198
Ki
5900000±n/a nM
Citation
 Hampton, A; Picker, D; Nealy, KA; Maeda, M Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 4. Interactions of adenosine 5'-triphosphate derivatives with adenylate kinases from Escherichia coli and rat tissues. J Med Chem 25:382-6 (1982) [PubMed]  Article 
Target
Name:
GTP:AMP phosphotransferase AK3, mitochondrial
Synonyms:
AK 3 | Adenylate kinase 3 | Adenylate kinase 3 alpha like 1 | Adenylate kinase 3 alpha-like 1 | Ak3 | Ak3l1 | Akl3l | GTP:AMP phosphotransferase mitochondrial | KAD3_RAT
Type:
PROTEIN
Mol. Mass.:
25443.58
Organism:
Rattus norvegicus
Description:
ChEMBL_1340551
Residue:
227
Sequence:
MGASGRLLRAVIMGAPGSGKGTGSSRITKHFELKHLSSGDLLRQNMLQGTEIAVLAKSFIDQGKLIPDDDMTRLALHELKNLTQCSWLLDGFPRTLPQAEALDRVYQIDTVINLNVPFEVIKLRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTETNKIRPHVYSFLQMKVPETIQKASVTP
  
Inhibitor
Name:
BDBM50367075
Synonyms:
CHEMBL3350513 | CHEMBL611859
Type:
Small organic molecule
Emp. Form.:
C14H22IN6O14P3
Mol. Mass.:
718.182
SMILES:
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(NCCNC(=O)CI)ncnc12 |r|
Structure:
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