Reaction Details Report a problem with these data
Target
Adenylate kinase 2, mitochondrial
Ligand
BDBM50367047
Substrate
n/a
Meas. Tech.
ChEMBL_32063 (CHEMBL644161)
Ki
21000000±n/a nM
Citation
 Hampton, A; Kappler, F; Picker, D Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity. J Med Chem 25:638-44 (1982) [PubMed]  Article 
Target
Name:
Adenylate kinase 2, mitochondrial
Synonyms:
2.7.4.3 | AK 2 | ATP-AMP transphosphorylase 2 | ATP:AMP phosphotransferase | Adenylate kinase 2 | Adenylate kinase 2, mitochondrial | Adenylate monophosphate kinase | Ak2 | KAD2_RAT
Type:
n/a
Mol. Mass.:
26380.21
Organism:
Rattus norvegicus
Description:
n/a
Residue:
239
Sequence:
MAPNALAPEPEHPEGIRAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRSDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFSKATCKDLVMFV
  
Inhibitor
Name:
BDBM50367047
Synonyms:
CHEMBL2368667
Type:
Small organic molecule
Emp. Form.:
C12H17N5NaO7PS
Mol. Mass.:
429.321
SMILES:
[Na+].CCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r|
Structure:
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