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Target
Neprilysin
Ligand
BDBM50027513
Substrate
n/a
Meas. Tech.
ChEBML_64504
IC50
11000±n/a nM
Citation
 Fournié-Zaluski, MC; Chaillet, P; Soroca-Lucas, E; Marçais-Collado, H; Costentin, J; Roques, BP New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties. J Med Chem 26:60-5 (1983) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_MOUSE
Type:
PROTEIN
Mol. Mass.:
85694.36
Organism:
Mus musculus
Description:
ChEMBL_144448
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLKLLPDIYGWPVASDNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50027513
Synonyms:
2-[2-(2-Carboxy-ethylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
Type:
Small organic molecule
Emp. Form.:
C18H24N2O5
Mol. Mass.:
348.3947
SMILES:
CC(C)CC(NC(=O)C(Cc1ccccc1)NCCC([O-])=O)C([O-])=O
Structure:
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