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TargetSteroid 5-alpha-reductase
LigandBDBM50025450
Substrate/Competitorn/a
Meas. Tech.ChEMBL_204733
Ki 1.7±n/a nM
Citation Rasmusson, GHReynolds, GFSteinberg, NGWalton, EPatel, GFLiang, TCascieri, MACheung, AHBrooks, JRBerman, C Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding. J Med Chem29:2298-315 (1986) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Steroid 5-alpha-reductase
Name:Steroid 5-alpha-reductase
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 204723
Components:This complex has 2 components.
Component 1
Name:Steroid 5-alpha-reductase
Synonyms:Steroid 5-alpha-reductase 1
Type:PROTEIN
Mol. Mass.:29788.29
Organism:Rattus norvegicus
Description:ChEMBL_1441437
Residue:259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQE
LPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLA
FLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE
TGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWY
HEKFEDYPKSRKILIPFVL
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Component 2
Name:Steroid 5-alpha-reductase
Synonyms:Steroid 5-alpha-reductase 2
Type:PROTEIN
Mol. Mass.:28784.15
Organism:Rattus norvegicus
Description:ChEMBL_205054
Residue:254
Sequence:
MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
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BDBM50025450
NameBDBM50025450
Synonyms:CHEMBL1790294 | Sodium; 1,4a,6a-trimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinoline-7-carboxylate
TypeSmall organic molecule
Emp. Form.C22H34NNaO3
Mol. Mass.383.5
SMILES[Na+].[H][C@@]12CC[C@H](C(C)C([O-])=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2N(C)C(=O)CC[C@]12C
Structure
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n/a