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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM50026197
Substrate
n/a
Meas. Tech.
ChEMBL_105120 (CHEMBL713238)
Ki
140000±n/a nM
Citation
 Kappler, F; Hai, TT; Hampton, A Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues. J Med Chem 29:318-22 (1986) [PubMed]  Article 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2
Type:
PROTEIN
Mol. Mass.:
43713.68
Organism:
Rattus norvegicus
Description:
ChEMBL_105118
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM50026197
Synonyms:
Adenosine 5'-triphosphate derivative | CHEMBL3142844
Type:
Small organic molecule
Emp. Form.:
C11H18N5O13P3
Mol. Mass.:
521.2076
SMILES:
CO[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12 |r|
Structure:
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