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Target
Glutamine synthetase
Ligand
BDBM50019955
Substrate
n/a
Meas. Tech.
ChEMBL_72156 (CHEMBL684451)
Ki
750000±n/a nM
Citation
 Farrington, GK; Kumar, A; Wedler, FC Design and synthesis of phosphonate inhibitors of glutamine synthetase. J Med Chem 30:2062-7 (1987) [PubMed]  Article 
Target
Name:
Glutamine synthetase
Synonyms:
GLNA_HUMAN | GLNS | GLUL | Glutamate decarboxylase
Type:
Protein
Mol. Mass.:
42066.51
Organism:
Homo sapiens (Human)
Description:
P15104
Residue:
373
Sequence:
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
  
Inhibitor
Name:
BDBM50019955
Synonyms:
2-ammonio-4-[hydroxy(phosphonomethyl)phosphoryl]butanoate
Type:
Small organic molecule
Emp. Form.:
C5H12NO7P2
Mol. Mass.:
260.0994
SMILES:
[NH3+]C(CCP([O-])(=O)CP(O)(O)=O)C([O-])=O
Structure:
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