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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50022418
Substrate
n/a
Meas. Tech.
ChEMBL_31633 (CHEMBL649694)
IC50
1000±n/a nM
Citation
 Sarges, R; Schnur, RC; Belletire, JL; Peterson, MJ Spiro hydantoin aldose reductase inhibitors. J Med Chem 31:230-43 (1988) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50022418
Synonyms:
(1-Carboxymethyl-cyclopentyl)-acetic acid(TMG) | 3,3-tetramethyleneglutaric acid | CHEMBL80679
Type:
Small organic molecule
Emp. Form.:
C9H14O4
Mol. Mass.:
186.2051
SMILES:
OC(=O)CC1(CC(O)=O)CCCC1
Structure:
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