Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50022415
Substrate
n/a
Meas. Tech.
ChEBML_31633
IC50
100±n/a nM
Citation
 Sarges, R; Schnur, RC; Belletire, JL; Peterson, MJ Spiro hydantoin aldose reductase inhibitors. J Med Chem 31:230-43 (1988) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50022415
Synonyms:
6-chloro-(4'S)-spiro[3,4-dihydro-2H-chromene-4,5'-(dihydro[1,3]oxazolane)]-2',4'-dione | CHEMBL79198
Type:
Small organic molecule
Emp. Form.:
C11H8ClNO4
Mol. Mass.:
253.639
SMILES:
OC1=NC(=O)[C@@]2(CCOc3ccc(Cl)cc23)O1 |t:1|
Structure:
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