Reaction Details Report a problem with these data
Target
Cytosol aminopeptidase
Ligand
BDBM50022747
Substrate
n/a
Meas. Tech.
ChEBML_98398
Ki
330±n/a nM
Citation
 Ocain, TD; Rich, DH Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues. J Med Chem 31:2193-9 (1988) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_HUMAN | Aminopeptidase | LAP3 | LAPEP | Leucine aminopeptidase | PEPS
Type:
PROTEIN
Mol. Mass.:
56171.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507539
Residue:
519
Sequence:
MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA
  
Inhibitor
Name:
BDBM50022747
Synonyms:
2-(3-Amino-2-hydroxy-4-phenyl-thiobutyrylamino)-4-methyl-pentanoic acid; TFA | CHEMBL304141 | CHEMBL68979
Type:
Small organic molecule
Emp. Form.:
C16H24N2O3S
Mol. Mass.:
324.438
SMILES:
CC(C)C[C@H](NC(=S)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Structure:
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