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Target
Thymidylate kinase
Ligand
BDBM50367697
Substrate
n/a
Meas. Tech.
ChEBML_208561
IC50
340000±n/a nM
Citation
 Davies, LC; Stock, JA; Barrie, SE; Orr, RM; Harrap, KR Dinucleotide analogues as inhibitors of thymidine kinase, thymidylate kinase, and ribonucleotide reductase. J Med Chem 31:1305-8 (1988) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
CDC8 | DTYMK | KTHY_HUMAN | TMPK | TYMK
Type:
PROTEIN
Mol. Mass.:
23824.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_946051
Residue:
212
Sequence:
MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDASKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
  
Inhibitor
Name:
BDBM50367697
Synonyms:
CHEMBL606301
Type:
Small organic molecule
Emp. Form.:
C21H31N7O19P4
Mol. Mass.:
809.4014
SMILES:
Cc1cn(C2C[C@H](O)[C@@H](COP(O)(=O)CP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3OC([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O |r|
Structure:
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