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Target
Adenosylhomocysteinase
Ligand
BDBM50023886
Substrate
n/a
Meas. Tech.
ChEBML_197366
IC50
110000±n/a nM
Citation
 Borcherding, DR; Narayanan, S; Hasobe, M; McKee, JG; Keller, BT; Borchardt, RT Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem 31:1729-38 (1988) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | AdoHcyase | Ahcy | CUBP | Liver copper-binding protein | S-adenosyl-L-homocysteine hydrolase | SAHH_MOUSE
Type:
PROTEIN
Mol. Mass.:
47687.65
Organism:
Mus musculus
Description:
ChEMBL_196559
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
  
Inhibitor
Name:
BDBM50023886
Synonyms:
2-[2-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-ethylidene]-propane-1,3-diol | CHEMBL50600
Type:
Small organic molecule
Emp. Form.:
C11H14N4O2
Mol. Mass.:
234.2545
SMILES:
[#7]-c1nccc2n(-[#6]\[#6]=[#6](/[#6]-[#8])-[#6]-[#8])cnc12
Structure:
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