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Target
D(2) dopamine receptor
Ligand
BDBM50017439
Substrate
n/a
Meas. Tech.
ChEMBL_62577 (CHEMBL671508)
Ki
2000±n/a nM
Citation
 Abou-Gharbia, M; Moyer, JA; Patel, U; Webb, M; Schiehser, G; Andree, T; Haskins, JT Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents. J Med Chem 32:1024-33 (1989) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rat
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50017439
Synonyms:
3,3-Dioxo-4-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-butyl]-3lambda*6*-thia-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-en-5-one; dihydrochloride | CHEMBL3215739
Type:
Small organic molecule
Emp. Form.:
C21H31Cl2N5O3S
Mol. Mass.:
504.474
SMILES:
Cl.Cl.O=C1C2C(C3CCC2C=C3)S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 |c:9|
Structure:
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