Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM13014
Substrate
n/a
Meas. Tech.
ChEBML_152586
Ki
3±n/a nM
Citation
 Girard, GR; Bondinell, WE; Hillegass, LM; Holden, KG; Pendleton, RG; Uzinskas, I Tetrahydrothiadiazoloisoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase. J Med Chem 32:1566-71 (1989) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM13014
Synonyms:
7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydrochloride | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | CHEMBL287837 | CHEMBL541797 | SKF 64139 | tetrahydroisoquinoline (THIQ) analogue
Type:
Small organic molecule
Emp. Form.:
C9H9Cl2N
Mol. Mass.:
202.08
SMILES:
Clc1ccc2CCNCc2c1Cl
Structure:
Search PDB for entries with ligand similarity: