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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50014239
Substrate
n/a
Meas. Tech.
ChEBML_131452
Ki
14±n/a nM
Citation
 Maryanoff, BE; Vaught, JL; Shank, RP; McComsey, DF; Costanzo, MJ; Nortey, SO Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J Med Chem 33:2793-7 (1990) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Norepinephrine transporter | SC6A2_MOUSE | Slc6a2 | Sodium-dependent noradrenaline transporter
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69260.85
Organism:
MOUSE
Description:
Norepinephrine transporter 0 MOUSE::O55192
Residue:
617
Sequence:
MLLARMNPQVQPELGGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
  
Inhibitor
Name:
BDBM50014239
Synonyms:
4-(1,2,3,5,6,10b-Hexahydro-pyrrolo[2,1-a]isoquinolin-6-yl)-benzonitrile | CHEMBL329216
Type:
Small organic molecule
Emp. Form.:
C19H18N2
Mol. Mass.:
274.3596
SMILES:
N#Cc1ccc(cc1)C1CN2CCCC2c2ccccc12
Structure:
Search PDB for entries with ligand similarity: