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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50015719
Substrate
n/a
Meas. Tech.
ChEBML_140172
Kd
10±n/a nM
Citation
 Cereda, E; Ezhaya, A; Gil Quintero, M; Bellora, E; Dubini, E; Micheletti, R; Schiavone, A; Brambilla, A; Schiavi, GB; Donetti, A Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads. J Med Chem 33:2108-13 (1990) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50015719
Synonyms:
3-Hydroxy-2-phenyl-propionic acid 9-iminomethyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester; hydrochloride | CHEMBL544993
Type:
Small organic molecule
Emp. Form.:
C17H20N2O4
Mol. Mass.:
316.3517
SMILES:
OCC(C(=O)OC1CC2C3OC3C(C1)N2C=N)c1ccccc1 |TLB:10:11:14:7.13.6,10:9:14:7.13.6|
Structure:
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