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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50015728
Substrate
n/a
Meas. Tech.
ChEBML_140172
Kd
2.7±n/a nM
Citation
 Cereda, E; Ezhaya, A; Gil Quintero, M; Bellora, E; Dubini, E; Micheletti, R; Schiavone, A; Brambilla, A; Schiavi, GB; Donetti, A Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads. J Med Chem 33:2108-13 (1990) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50015728
Synonyms:
3-(3-Hydroxy-2-phenyl-propionyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane; bromide(atropine methyl bromide) | CHEMBL63452
Type:
Small organic molecule
Emp. Form.:
C18H26NO3
Mol. Mass.:
304.4034
SMILES:
C[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)c1ccccc1
Structure:
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