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Target
S-adenosylmethionine synthase isoform type-1
Ligand
BDBM50368141
Substrate
n/a
Meas. Tech.
ChEMBL_104976 (CHEMBL715656)
Ki
100000±n/a nM
Citation
 Kappler, F; Hampton, A Approaches to isozyme-specific inhibitors. 17. Attachment of a selectivity-inducing substituent to a multisubstrate adduct. Implications for facilitated design of potent, isozyme-selective inhibitors. J Med Chem 33:2545-51 (1990) [PubMed]  Article 
Target
Name:
S-adenosylmethionine synthase isoform type-1
Synonyms:
AdoMet synthetase 1 | Ams1 | MAT 1 | MAT-I/III | METK1_RAT | Mat1a | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1
Type:
PROTEIN
Mol. Mass.:
43692.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11027
Residue:
397
Sequence:
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
  
Inhibitor
Name:
BDBM50368141
Synonyms:
CHEMBL3706400 | CHEMBL610658
Type:
Small organic molecule
Emp. Form.:
C14H23N4O13P3S
Mol. Mass.:
580.338
SMILES:
CCCCSc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
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